Ace the 2025 2PD Top 200 Drugs Challenge: Master Anti-Infectives & Cardiovascular Agents!

Atorvastatin, a medication widely used to lower cholesterol and reduce the risk of cardiovascular disease, has specific precautions that patients need to be aware of to ensure its efficacy and reduce the risk of adverse effects. One important precaution is to avoid excessive alcohol consumption and grapefruit.

Excessive alcohol intake can increase the risk of liver damage, which is particularly significant since atorvastatin is metabolized in the liver. Therefore, patients are advised to limit alcohol consumption while on atorvastatin to protect liver function.

Grapefruit and grapefruit juice are also known to interfere with the metabolism of atorvastatin. They contain compounds that inhibit the enzyme CYP3A4, which is responsible for breaking down atorvastatin in the liver. Consuming grapefruit can lead to increased levels of the medication in the bloodstream, heightening the risk of muscle-related side effects, such as myopathy or rhabdomyolysis.

By understanding these precautions, patients can better manage their treatment with atorvastatin and minimize potential risks associated with the medication.